Since September 2007, Hough has become known for his work on the ABC dance-competition series, Dancing with the Stars, on which he has won a record six seasons. With a total of eight nominations, he has won two Primetime Emmy Awards for Outstanding Choreography for several routines that he choreographed for the show. Hough has also starred in various stage productions, including the 2006 original production of Footloose: The Musical at the Novello Theatre in London's West End, as well as the 2015 New York Spring Spectacular at Radio City Music Hall in New York City. In 2013, he starred in Make Your Move, a Romeo and Juliet-inspired South Korean-American independent dance film. As of 2014, he has held a recurring acting role on ABC's musical-drama, Nashville.
On December 7, 2016, Hough played the role of Corny Collins in NBC's live musical TV-production, Hairspray Live! He is set to star as Don Lockwood in the upcoming Broadway production of Singin' in the Rain.